Intrepid biohacker gives himself infrared night vision, but at what price?

According to the World War II-era nautical lore, the Navy wanted sailors that could see IR signals. To this end volunteers were fed a diet that was missing the form of vitamin A normally used to make photopigments for our visual system. They were instead given supplements of an alternate form of the vitamin that gave sensitivity into the IR spectrum. While invention of the sniperscope brought these dubious experiments to a premature close, a group of biohackers has been inspired to pick up right where the early transhumanist pioneers left off.

Eyes are remarkably adaptable machines. Animals have morphed them into exotic polarization sensors, magnetic field orienteering aids, and even single photon detectors. An interesting anecdote from the astronautical lore is that flashes of light — generally attributed to cosmic rays — have been perceived by astronauts even with their eyes were closed. While it is possible that these figments are triggered in the brain, it seems more likely that the retina, perhaps even the photopigments themselves, are directly sensing energy deposited by the rays and realizing it as light. With the right photopigment, seamless detection of IR should be a piece of cake.

The only problem is that lack of vitamin A claims the lives of around a million children worldwide each year, and it is responsible for blindness in half that again. An intrepid group of four biohackers hope that the replacement form of vitamin A, known as vitamin A2, will compensate completely. A2 is found in freshwater fish, and can be extracted (with some effort) from their livers. The group has created a project based on a “Microryza” crowdfunding model, and is now funded to the tune of $4,000. (Read: Seeing ultraviolet, exploring color.)

This is what our intrepid senior editor, Sebastian Anthony, looks like with thermal IR.

Much of the capital raised will be used to procure the vitamin itself. Additionally there will be funds for sensitive equipment to measure the electrical responses of the eye as its spectral sensitivity changes. Their results will be published in an open, peer-reviewed research journal. The diet thebiohackers will use has been developed bycomputer engineer Rob Rhinehart, creator of a successful life-optimizing drink known as Soylent. Crowdfunded itself, Soylent also enjoys high-profile backing from venture capitalists like Andreessen Horowitz.

Vitamin A, and its precursors like beta-carotene, are metabolized into different forms that are used in various ways all throughout the body. Its ability to melt wrinkles or pimples when applied to the skin hints at its powers once inside a cell’s nucleus, where it has its main effects. The kicker in prescription drug Accutane is a vitamin A derivative called retinoic acid. This acid is actually the go molecule used in a developing embryo when it begins to push out the upper limb buds. Retinoic acid is a master regulator molecule that “turns on” other genes to get the bits and pieces of the arm just right.

The Milky Way, as seen by NASA’s infrared Spitzer telescope. I doubt it would look like this with biohacked eyes, but it’s nice to dream…

If you aren’t scared yet, consider one more thing: vitamin A deprived rats developed hypogonadism (reduced gonad functionality). This happened even when they were fed the retinoic acid that is needed by the testes because they are actually a bit pickier than that — they need locally-synthesized retinoic acid to actually do the trick. The good news is that inhibiting retinoic acid makes a wonderful birth control in humans, and that has even been promoted as a male contraceptive. One further word of caution is in order. While the body can in fact metabolize the fishy A2 vitamin form, the proteins that transport it through cell membranes are only one-quarter as efficient at binding and taking up the A2 form.

Researchers sometimes seem to be motivated by fame and glory as much as by science. There may be a hint of that here, but transhumanists see themselves more as individual medical explorers than as medical trials guinea pigs with no control over their fate. (Read:What is transhumanism, or, what does it mean to be human?) That being said, one indication that times are tough in the academic research arena is the recent report of the guy who published a study of the absolute worst places to be stung, in descending order — with himself as the subject. While there may be some value in research like that, it reminds one of the guy who ate a bicycle just to get into the Guinness book of World records. Fortunately for him, Guinness published it, but only with a note saying this will be the last time for things like that.